Nuclear Phosphoinositides as Key Determinants of Nuclear Functions

Polyphosphoinositides (PPIns) are signalling messengers representing less than five per cent of the total phospholipid concentration within cell. Despite their low concentration, these lipids critical regulators various cellular processes, including cell cycle, differentiation, gene transcription, apoptosis and motility. PPIns generated by phosphorylation inositol head group phosphatidylinositol (PtdIns). Different pools found at distinct subcellular compartments, which regulated an array kinases, phosphatases phospholipases. Six seven species have been in nucleus, nuclear envelope, nucleoplasm nucleolus. The identification characterisation interactor effector proteins nucleus led to increasing interest role signalling. However, regulation functions complex still being elucidated. This review summarises our current understanding localisation, biogenesis physiological different nucleus.